Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury

Proceedings of the National Academy of Sciences, Volume 122, Issue 21, May 2025.
SignificanceKoh et al. show that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is pathologically elevated in human and mouse Alzheimer’s disease (AD), traumatic brain injury (TBI), and aging, with 15-PGDH localized to myeloid cells of the blood–brain …
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