Metabolic engineering of Bacillus subtilis for the production of active hemoglobins and myoglobins by improving heme supply

Proceedings of the National Academy of Sciences, Volume 122, Issue 27, July 2025.
SignificanceThe large-scale biosynthesis of active hemoproteins for applications in the manufacture of food and medicine remains a significant challenge. In this study, we comprehensively identified bottlenecks in the heme biosynthetic pathway and …
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