Oxidative pentose phosphate pathway is required for T cell activation and antitumor immunity

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025.
SignificanceThe most frequent human enzyme deficiency involves glucose-6-phosphate dehydrogenase (G6PD), the committed enzyme of the oxidative pentose phosphate pathway. Mild G6PD deficiency protects against malaria at the expense of fragile red blood …
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