Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase

Proceedings of the National Academy of Sciences, Volume 123, Issue 19, May 2026.
SignificanceRibonucleotide reductases (RNRs) are ancient enzymes responsible for the synthesis of deoxyribonucleotides from ribonucleotides. RNRs catalyze this reaction via a long-range proton-coupled electron transfer (PCET) process, involving the …
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